Influence of SIRT6 Knock Down on Stability of β-Catenin in Non- Small Cell Lung Cancer Cell Line

Abstract

Sirtuins are a class of NAD+-dependent proteins that play a key role in regulating lifespan and preserving metabolic equilibrium. According to reports, sirtuin 6 (SIRT6) may have an oncogenic effect on lung cancer. Nevertheless, it is unclear exactly how SIRT6 functions at the molecular level in human lung cancer. For lung cancer to continue, Wnt signalling must be properly regulated. It is still mostly unclear how Wnt signalling is epigenetically regulated in NSCLC. As a result, we looked at how crucial the SIRT6 function is in A549 and H460. In human NSCLC, SIRT6 was substantially expressed. NSCLC cell viability was markedly reduced when SIRT6 was silenced. β-catenin is less phosphorylated when SIRT6 is knocked down. These results suggest that SIRT6 inhibition may increase the quantities of active β-catenin protein in NSCLC, which in turn may influence WNT signaling.