Development of Albendazole Nanodispersion for the Effective Treatment of Helminthiasis

Abstract

Albendazole is a drug used to treat parasitic worm infections. ALB results in the tegument and intestinal cells of the worm undergoing degenerative changes, which ultimately lead the parasite to become immobile and die. The purpose of the study was to improve the solubility and effectiveness of an ALB-loaded solid nano dispersion for the effective treatment of helminthiasis.ALBFs were generated by a solvent evaporation procedure involving PVPK30 and carbopol, which may improve the stability of controlled drug release rates. The newly found ALBFs are more soluble than pure albendazole and have a better bioavailability. ALBFs allow for the optimization of therapeutic efficacy while lowering potential side effects and modulating enzymatic resistance, degradation, and drug release rate. Thus, the created ALBFs demonstrated successful helminthiasis treatment with lower dose frequency.