Protective Role of Evolvulus Alsinoides Linn. on Chemical Induced Prostatitis in Male Albino Rats

  • L Gomathirajashyamala Department of Nutrition and Dietetics, Alagappa University, Karaikudi, Tamilnadu, India
  • R Ramya Department of Nutrition and Dietetics, Alagappa University, Karaikudi, Tamilnadu, India
  • P Rameshthangam Department of Nutrition and Dietetics, Alagappa University, Karaikudi, Tamilnadu, India
Keywords: Prostatitis, Aluminum Chloride, Evlovulusalsinoides. L.PSA, Cytokines, LH, FSH, Progesterone, Testosterone

Abstract

“Evolvulus alsinoides Linn. (Vishnu Kiranti) plant is widely used as antibacterial and anthelmintic, anti-stress and anti-amnesic and a good memory tonic”.The present this study aimed to investigate the protective role of Evolvulus alsinoides L.on the inflammatory effects of AlCl3 induced prostatitis in rat model.Prostatitis was induced in male Wistar rats (n=24) treated with AlCl3 for 12 weeks. Following prostatitis induction, the rats were randomly assigned to one of four treatment groups: normal control (NC-group), prostatitis (AlCl3-group), Evolvulusalsinoides methanolic extract (EAME group), and AlCl3+EAME group. The animals were giventheir routinediets throughout the study period. The parameters including Reproductive hormones, inflammatory markers and Prostate Specific Antigen (PSA), were evaluated.The histopathological changes in the prostate were also studied. The results showed that there was a significant (p<0.05) reduction in PSA levels and a significant (p<0.05) increase in reproductive hormones, including LH, FSH, Progesterone, Testosterone, and Estradiol levels, in groups fed with EAME. The study concluded that the EAMEhad aneffective anti-inflammatory property, and histological examinations revealed a significant improvement in the prostatic histoarchitecture of groups fed EAME. Our research findings suggest that EAME is beneficial in the prevention and treatment of nonbacterial prostatitis.

Published
2024-07-10
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